Medicine and Health

Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant

G. R. F. Campos, N. B. F. Almeida, et al.

This groundbreaking study highlights the remarkable effect of a BNT162b2 mRNA vaccine booster dose on antibody neutralization against the SARS-CoV-2 Omicron variant. The research shows a dramatic increase in seroconversion rates from 10% to 76.6% after the booster, showcasing the enhanced immune response facilitated by this combined vaccination strategy. Conducted by a team of experts, this research offers significant insights into vaccine efficacy in combating emerging variants.

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Abstract

This study evaluated the impact of a BNT162b2 mRNA vaccine booster dose on antibody neutralization against the SARS-CoV-2 Omicron variant in 90 individuals after a primary CoronaVac vaccination scheme. Results showed that the seroconversion rate increased significantly from 10% to 76.6% after the booster dose, with a 43.1-fold increase in the mean neutralization titer against Omicron. This indicates a positive impact of the combined vaccination strategy on the immune response against the Omicron variant.

Publisher

COMMUNICATIONS MEDICINE

Published On

Authors

Guilherme R F Campos, Nathalie Bonatti Franco Almeida, Priscilla Soares Filgueiras, Camila Amorimno Corsini, Sarah Vieira Contin Gomes, Daniel Alvim Pena de Miranda, Jéssica Vieira de Assis, Thaís Bárbara de Souza Silva, Pedro Augusto Alves, Gabriel da Rocha Fernandes, Jaqueline Germano de Oliveira, Paula Raha, Rafaella Fortini Queiroz Grenfell, Maurício L Nogueira

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