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Abstract
The study characterized a human antibody, 586G, with potent neutralizing activity against SARS-CoV-2 Delta and Omicron variants. Nasal delivery of 586G showed prophylactic and therapeutic efficacy in hamsters, preventing viral replication in the lungs at a low dose (2 mg/kg daily). This antibody is a promising candidate for treating COVID-19, potentially overcoming limitations of currently approved antibodies.
Publisher
Signal Transduction and Targeted Therapy
Published On
Aug 30, 2022
Authors
Xinghai Zhang, Huajun Zhang, Tingting Li, Shaohong Chen, Feiyang Luo, Junhui Zhou, Peiyi Zheng, Shuyi Song, Yan Wu, Tengchuan Jin, Ni Tang, Chengyong Yang, Guofeng Cheng, Ruil Gong, Sandra Chiu, Ailong Huang
Tags
SARS-CoV-2
586G antibody
Delta variant
Omicron variant
nasal delivery
COVID-19 treatment
viral replication

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