Medicine and Health

A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

X. Zhang, H. Zhang, et al.

Discover a groundbreaking study that showcases the human antibody 586G, demonstrating robust neutralizing effects against the Delta and Omicron variants of SARS-CoV-2. Remarkably effective through nasal delivery, 586G not only prevents viral replication in lungs but does so with a low daily dose, making it a strong candidate for future COVID-19 treatments. This innovative research was conducted by Xinghai Zhang, Huajun Zhang, Tingting Li, Shaohong Chen, Feiyang Luo, Junhui Zhou, Peiyi Zheng, Shuyi Song, Yan Wu, Tengchuan Jin, Ni Tang, Chengyong Yang, Guofeng Cheng, Ruil Gong, Sandra Chiu, and Ailong Huang.

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Abstract

The study characterized a human antibody, 586G, with potent neutralizing activity against SARS-CoV-2 Delta and Omicron variants. Nasal delivery of 586G showed prophylactic and therapeutic efficacy in hamsters, preventing viral replication in the lungs at a low dose (2 mg/kg daily). This antibody is a promising candidate for treating COVID-19, potentially overcoming limitations of currently approved antibodies.

Publisher

Signal Transduction and Targeted Therapy

Published On

Aug 30, 2022

Authors

Xinghai Zhang, Huajun Zhang, Tingting Li, Shaohong Chen, Feiyang Luo, Junhui Zhou, Peiyi Zheng, Shuyi Song, Yan Wu, Tengchuan Jin, Ni Tang, Chengyong Yang, Guofeng Cheng, Ruil Gong, Sandra Chiu, Ailong Huang

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