This research paper investigates broadly neutralizing antibodies (bnAbs) against Omicron and other SARS-CoV-2 variants, induced by vaccination with an adenovirus-vectored COVID-19 vaccine (Ad5-nCoV). The study identifies a monoclonal antibody (mAb), ZWD12, which shows potent and broad neutralization against multiple variants, including Omicron. Cryo-electron microscopy was used to determine the ZWD12 epitope, revealing its interaction with the spike protein. The findings suggest potential for developing broadly therapeutic mAb drugs and inform the design of broad-spectrum vaccines.

Xiangyang Chi, Yingying Guo, Guanying Zhang, Hancong Sun, Jun Zhang, Min Li, Zhengshan Chen, Jin Han, Yuanyuan Zhang, Xinghai Zhang, Pengfei Fan, Zhe Zhang, Busen Wang, Xiaodong Zai, Xuelian Han, Meng Hao, Ting Fang, Jinghan Xu, Shipo Wu, Yi Chen, Yingying Fang, Yunzhu Dong, Bingjie Sun, Jinlong Zhang, Jianmin Li, Guangyu Zhao, Changming Yu, Qiang Zhou, Wei Chen