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A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration

Medicine and Health

A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration

H. Ma, X. Zhang, et al.

This groundbreaking research conducted by Huan Ma, Xinghai Zhang, and colleagues unveils a bispecific nanobody that shows remarkable potency against the latest SARS-CoV-2 variants, providing hope for effective therapies against Omicron. With promising results from animal studies, the future looks bright for preventing COVID-19 infections.

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Playback language: English
Abstract
Current SARS-CoV-2 Omicron subvariants evade immunity from most neutralizing antibodies and vaccines. This study identified a nanobody (aS3A) cross-reactive with SARS-CoV-1 and SARS-CoV-2 RBD. A bispecific nanobody dimer (2-3-Fc), engineered by fusing aS3A-Fc to aRBD-2, exhibited potent neutralization against all major variants of concern, including BA.5. In hamsters, a single systemic dose (10 mg/kg) or a lower intranasal dose (5 mg/kg) of 2-3-Fc provided complete or drastic protection against Omicron infection, respectively. A variant, Y296-3-Fc, showed enhanced neutralization of BA.2.75. This research provides potential therapeutic and prophylactic candidates against SARS-CoV-2 variants.
Publisher
Cell Discovery
Published On
Authors
Huan Ma, Xinghai Zhang, Weihong Zeng, Junhui Zhou, Xiangyang Chi, Shaohong Chen, Peiyi Zheng, Meihua Wang, Yan Wu, Dan Zhao, Fanwu Gong, Haofeng Lin, Hancong Sun, Changming Yu, Zhengli Shi, Xiaowen Hu, Huajun Zhang, Tengchuan Jin, Sandra Chiu
Tags
SARS-CoV-2
Omicron
nanobody
neutralization
therapeutic candidates
vaccine evasion
variant protection
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