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Abstract
This study evaluated the impact of a BNT162b2 mRNA vaccine booster dose on antibody neutralization against the SARS-CoV-2 Omicron variant in 90 individuals after a primary CoronaVac vaccination scheme. Results showed that the seroconversion rate increased significantly from 10% to 76.6% after the booster dose, with a 43.1-fold increase in the mean neutralization titer against Omicron. This indicates a positive impact of the combined vaccination strategy on the immune response against the Omicron variant.
Publisher
COMMUNICATIONS MEDICINE
Published On
Authors
Guilherme R F Campos, Nathalie Bonatti Franco Almeida, Priscilla Soares Filgueiras, Camila Amorimno Corsini, Sarah Vieira Contin Gomes, Daniel Alvim Pena de Miranda, Jéssica Vieira de Assis, Thaís Bárbara de Souza Silva, Pedro Augusto Alves, Gabriel da Rocha Fernandes, Jaqueline Germano de Oliveira, Paula Raha, Rafaella Fortini Queiroz Grenfell, Maurício L Nogueira
Tags
BNT162b2 vaccine
mRNA booster
SARS-CoV-2
Omicron variant
seroconversion rate
antibody neutralization
vaccination strategy

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