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Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

Medicine and Health

Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

J. Zou, C. Kurhade, et al.

This study reveals the comprehensive cross-neutralization of Omicron sublineages BA.1, BA.2, and BA.3, shedding light on the varying effectiveness of neutralization in sera from BA.1-infected individuals. Conducted by experts from the University of Texas Medical Branch, this research underscores critical considerations for future COVID-19 vaccine strategies.

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Playback language: English
Abstract
This study investigates the cross-neutralization of Omicron sublineages BA.1, BA.2, and BA.3. Sera from BA.1-infected individuals neutralized BA.1, BA.2, BA.3, and a pre-Omicron strain (USA/WA1-2020). While effective against BA.1, neutralization against BA.2 and BA.3 was significantly reduced (4.2- and 4.4-fold, respectively), highlighting the need for consideration in COVID-19 vaccine strategies.
Publisher
Nature Communications
Published On
May 26, 2022
Authors
Jing Zou, Chaitanya Kurhade, Hongjie Xia, Mingru Liu, Xuping Xie, Ping Ren, Pei-Yong Shi
Tags
Omicron
neutralization
BA.1
BA.2
COVID-19
vaccine strategies
serum

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