Medicine and Health

Biomarkers of central and peripheral inflammation mediate the association between HIV and depressive symptoms

A. M. Rakhasa-loos, N. Bakewell, et al.

This study reveals groundbreaking insights into the connection between HIV and depressive symptoms, highlighting the role of inflammatory biomarkers. Conducted by prominent researchers including Arish Muda Rakhasa-Loos and Nicholas Bakewell, it unveils how inflammation may drive depression in HIV-positive individuals, a critical factor for healthcare providers.

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Abstract

This study investigated the mediating role of peripheral and central inflammatory biomarkers in the association between HIV and depressive symptoms. 125 HIV-positive and 79 HIV-negative individuals were studied. HIV-positive participants were more likely to experience depressive symptoms. Plasma MIG and TNF-α, and CSF MIP-1α and IL-6 mediated the association between HIV and depressive symptoms. The findings suggest that inflammation may contribute to HIV-associated depression.

Publisher

Translational Psychiatry

Published On

Jun 06, 2023

Authors

Arish Muda Rakhasa-Loos, Nicholas Bakewell, David J. Sharp, Magnus Gisslén, Henrik Zetterberg, Jasmini Alagaratnam, Ferdinand W. N. M. Witte, Neeltje A. Kootstra, Alan Winston, Peter Reiss, Caroline A. Sabin, Jaime H. Vera

DOI

https://doi.org/10.1038/s41398-023-02489-0

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