This study investigated the mediating role of peripheral and central inflammatory biomarkers in the association between HIV and depressive symptoms. 125 HIV-positive and 79 HIV-negative individuals were studied. HIV-positive participants were more likely to experience depressive symptoms. Plasma MIG and TNF-α, and CSF MIP-1α and IL-6 mediated the association between HIV and depressive symptoms. The findings suggest that inflammation may contribute to HIV-associated depression.
Publisher
Translational Psychiatry
Published On
Jun 06, 2023
Authors
Arish Muda Rakhasa-Loos, Nicholas Bakewell, David J. Sharp, Magnus Gisslén, Henrik Zetterberg, Jasmini Alagaratnam, Ferdinand W. N. M. Witte, Neeltje A. Kootstra, Alan Winston, Peter Reiss, Caroline A. Sabin, Jaime H. Vera
