Medicine and Health

Baseline ctDNA gene alterations as a biomarker of survival after panitumumab and chemotherapy in metastatic colorectal cancer

K. Shitara, K. Muro, et al.

In the exciting Phase 3 PARADIGM trial involving 733 participants, researchers investigated how circulating tumor DNA (ctDNA) gene alterations impact treatment outcomes in RAS wild-type metastatic colorectal cancer. Discover whether first-line therapy using panitumumab could provide longer survival rates for patients without ctDNA alterations, as highlighted by the team of experts led by Kohei Shitara and Kei Muro.

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Abstract

This phase 3 PARADIGM trial (n=733) investigated the association between circulating tumor DNA (ctDNA) gene alterations and efficacy outcomes in patients with RAS wild-type metastatic colorectal cancer (mCRC) treated with first-line panitumumab plus modified FOLFOX6 or bevacizumab plus modified FOLFOX6. Overall survival was longer with panitumumab in patients with ctDNA lacking gene alterations (negative hyperselected), but similar or inferior in those with any ctDNA alteration, regardless of tumor sidedness. Negative hyperselection using ctDNA may guide optimal treatment selection.

Publisher

Nature Medicine

Published On

Mar 01, 2024

Authors

Kohei Shitara, Kei Muro, Jun Watanabe, Kentaro Yamazaki, Hisatsugu Ohori, Manabu Shiozawa, Atsuo Takashima, Mitsuru Yokota, Akitaka Makiyama, Naoya Akazawa, Hitoshi Ojima, Yasuhiro Yuasa, Keisuke Miwa, Hirofumi Yasui, Eiji Oki, Takeo Sato, Takeshi Naitoh, Yoshito Komatsu, Takeshi Kato, Ikuo Mori, Kazunori Yamanaka, Masamitsu Hihara, Junpei Soeda, Toshihiro Misumi, Kouji Yamamoto, Riu Yamashita, Kiwamu Akagi, Atsushi Ochiai, Hiroyuki Uetake, Katsuya Tsuchihara, Takayuki Yoshino

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