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Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21

Medicine and Health

Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21

S. S. Leventhal, T. Bisom, et al.

Discover groundbreaking research on the Crimean-Congo Hemorrhagic Fever Virus, revealing how a self-replicating RNA vaccine induces neutralizing antibodies and protective immunity through TRIM21. This exciting study by Shanna S Leventhal and colleagues sheds new light on the mechanisms of protection against this lethal virus.

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Playback language: English
Abstract
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus with no widely approved or highly efficacious interventions. A self-replicating alphavirus-based RNA vaccine expressing the CCHFV nucleoprotein (NP) is protective. This study shows this vaccine generates neutralizing anti-N antibodies and that protection doesn't require Fc-gamma receptors or complement. Instead, protection is mediated by TRIM21, and passive transfer of NP-immune antibodies provides TRIM21-dependent protection against lethal CCHFV challenge. This identifies TRIM21-mediated mechanisms as the effective function of protective antibodies against CCHFV NP.
Publisher
Nature Communications
Published On
Oct 25, 2024
Authors
Shanna S Leventhal, Thomas Bisom, Dean Clúft, Deepashri Rao, Kimberly Meade-White, Carl Chaia, Justin Murray, Evan A Mihalakos, Troy Hinkley, Steven J Reynolds, Sonja M Best, Jesse H Erasmus, Leo C James, Heinz Feldmann, David W Hawman
Tags
CCHFV
RNA vaccine
neutralizing antibodies
TRIM21
protection

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