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An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters

Medicine and Health

An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters

S. Deng, Y. Liu, et al.

This groundbreaking study by Shaofeng Deng and colleagues introduces an intranasal vaccine, DelNS1-RBD4N-DAF, that not only induced strong immune responses in animal models but also effectively prevented SARS-CoV-2 replication in respiratory tissues, outperforming traditional intramuscular vaccines. This promising LAIV could change the game in controlling COVID-19 transmission.

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