Biology

All-optical voltage interrogation for probing synaptic plasticity in vivo

J. Carolan, M. A. Land, et al.

We developed an all-optical approach to probe synaptic plasticity at identified cerebellar synapses in awake, behaving mice, using JEDI-2Psub to record Purkinje cell dendritic activity while selectively activating granule cell and climbing fiber inputs, revealing how pairing granule cell activation with sensory-evoked climbing fiber inputs triggers long-term plasticity of inhibitory responses in Purkinje cells. Research conducted by the authors present in the <Authors> tag.