Alantolactone attenuates high-fat diet-induced inflammation and | ResearchBunny

Index

Abstract

This study investigated the therapeutic effect of Alantolactone (Ala) on Nonalcoholic fatty liver disease (NAFLD). C57BL/6 mice were fed a high-fat diet (HFD) to induce NAFLD, then treated with Ala. Ala significantly inhibited inflammation, fibrosis, and oxidative stress in HFD-induced mice and palmitic acid (PA)-induced AML-12 cells. Mechanistically, Ala's effect was linked to Nrf2 induction and NF-κB inhibition. These findings suggest Ala is a potential therapy for NAFLD by blocking inflammation and oxidative stress.

Publisher

Nutrition and Diabetes

Published On

Jun 10, 2024

Authors

Jiong Wang, Yucheng Jiang, Leiming Jin, Chenchen Qian, Wei Zuo, Jianjun Lin, Longteng Xie, Bo Jin, Yanni Zhao, Lijiang Huang, Yi Wang

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