Medicine and Health

Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer

Y. Jiang, J. Huang, et al.

Discover the groundbreaking research by Yuyan Jiang, Jiaguo Huang, Cheng Xu, and Kanyi Pu on a novel photothermally activatable polymeric pro-nanoagonist (APNA) that enhances combinational photothermal immunotherapy for cancer. This innovative approach utilizes deep-tissue-penetrating NIR-II light to trigger tumor ablation and boost systemic antitumor immunity.

00:00

Playback language: English

Index

Abstract

This paper reports a photothermally activatable polymeric pro-nanoagonist (APNA) for combinational photothermal immunotherapy of cancer, specifically regulated by deep-tissue-penetrating second near-infrared (NIR-II) light. APNA, composed of an immunostimulant (Resiquimod: R848) covalently conjugated to a NIR-II semiconducting transducer via a thermo-responsive linker, mediates photothermal effects upon NIR-II irradiation. This triggers tumor ablation, immunogenic cell death, and linker cleavage, liberating the agonist for in-situ immune activation. This controlled immune regulation enhances systemic antitumor immunity, inhibiting metastasis.

Publisher

Nature Communications

Published On

Feb 02, 2021

Authors

Yuyan Jiang, Jiaguo Huang, Cheng Xu, Kanyi Pu

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

The efficacy and adverse events of conventional and second-generation androgen receptor inhibitors for castration-resistant prostate cancer: A network meta-analysis

X. Zhang, G. Zhang, et al.

Chemistry

Optimal acceleration voltage for near-atomic resolution imaging of layer-stacked 2D polymer thin films

B. Liang, Y. Zhang, et al.

Space Sciences

Near-infrared observations of active asteroid (3200) Phaethon reveal no evidence for hydration

D. Takir, T. Kareta, et al.

Medicine and Health

Recent progress in the development of nanomaterials targeting multiple cancer metabolic pathways: a review of mechanistic approaches for cancer treatment

L. Zhang, B. Zhai, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny