Medicine and Health

The efficacy and adverse events of conventional and second-generation androgen receptor inhibitors for castration-resistant prostate cancer: A network meta-analysis

X. Zhang, G. Zhang, et al.

Discover the findings of an exciting network meta-analysis that uncovers the superior efficacy of second-generation androgen receptor inhibitors over conventional treatments for castration-resistant prostate cancer. This research was conducted by Xianlu Zhang, Gejun Zhang, Jianfeng Wang, Jianbin Bi, Xiaolan Deng, Yanlong Wang, and Yinu Wang.

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Playback language: English

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Abstract

This network meta-analysis compared the efficacy and adverse events of conventional (bicalutamide) and second-generation androgen receptor inhibitors (ARIs; enzalutamide, apalutamide, and darolutamide) in treating castration-resistant prostate cancer (CRPC). Seven randomized clinical trials (RCTs) involving 6,993 patients were analyzed. Second-generation ARIs were superior to bicalutamide in terms of progression-free survival (PFS), prostate-specific antigen (PSA) progression-free survival (PSA-PFS), and overall survival (OS). However, there were subtle differences among the second-generation ARIs; apalutamide showed a higher rate of Grade 3+ adverse events (AEs). All ARIs were generally well-tolerated.

Publisher

Frontiers in Endocrinology

Published On

Feb 10, 2023

Authors

Xianlu Zhang, Gejun Zhang, Jianfeng Wang, Jianbin Bi, Xiaolan Deng, Yanlong Wang, Yinu Wang

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