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Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats

Veterinary Science

Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats

D. M. Minaya, A. Turlej, et al.

This groundbreaking research conducted by Dulce M. Minaya and colleagues reveals that consumption of high energy density diets leads to significant changes in body composition, gut microbiome, and systemic inflammation in rats. Discover the early responses of microbiota dysbiosis and how these contribute to liver fat accumulation and brain microglia activation over the course of 26 weeks.

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Playback language: English
Abstract
Consumption of high energy density (HED) diets is associated with obesity. This study investigated the long-term (6 months) effects of an HED diet on body composition, gut microbiome, hepatic lipidosis, microglia activation in the nucleus of the solitary tract (NTS), and systemic inflammation in rats. Results showed that HED diet induced microbiota dysbiosis within a week, followed by microglia activation in the NTS and hepatic lipidosis after 4 weeks. Changes in serum cytokine profiles were observed after 26 weeks. This suggests that microbiota dysbiosis is an early response to HED diets, followed by liver fat accumulation, brain microglia activation, and increased inflammatory markers.
Publisher
Nutrition and Diabetes
Published On
Jun 09, 2020
Authors
Dulce M. Minaya, Anna Turlej, Abhinav Joshi, Tamas Nagy, Noah Weinstein, Patricia DiLorenzo, Andras Hajnal, Krzysztof Czaja
Tags
high energy density diet
obesity
gut microbiome
hepatic lipidosis
microglia activation
systemic inflammation
rats

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