logo
ResearchBunny Logo
Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats

Veterinary Science

Consumption of a high energy density diet triggers microbiota dysbiosis, hepatic lipidosis, and microglia activation in the nucleus of the solitary tract in rats

D. M. Minaya, A. Turlej, et al.

This groundbreaking research conducted by Dulce M. Minaya and colleagues reveals that consumption of high energy density diets leads to significant changes in body composition, gut microbiome, and systemic inflammation in rats. Discover the early responses of microbiota dysbiosis and how these contribute to liver fat accumulation and brain microglia activation over the course of 26 weeks.

00:00
00:00
Playback language: English
Abstract
Consumption of high energy density (HED) diets is associated with obesity. This study investigated the long-term (6 months) effects of an HED diet on body composition, gut microbiome, hepatic lipidosis, microglia activation in the nucleus of the solitary tract (NTS), and systemic inflammation in rats. Results showed that HED diet induced microbiota dysbiosis within a week, followed by microglia activation in the NTS and hepatic lipidosis after 4 weeks. Changes in serum cytokine profiles were observed after 26 weeks. This suggests that microbiota dysbiosis is an early response to HED diets, followed by liver fat accumulation, brain microglia activation, and increased inflammatory markers.
Publisher
Nutrition and Diabetes
Published On
Jun 09, 2020
Authors
Dulce M. Minaya, Anna Turlej, Abhinav Joshi, Tamas Nagy, Noah Weinstein, Patricia DiLorenzo, Andras Hajnal, Krzysztof Czaja
Tags
high energy density diet
obesity
gut microbiome
hepatic lipidosis
microglia activation
systemic inflammation
rats

Related Publications

Explore these studies to deepen your understanding of the subject.

MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet
Health and Fitness

MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet

F. Wang, M. Hu, et al.

A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota
Medicine and Health

A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota

Y. Guo, X. Zhu, et al.

Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice
Medicine and Health

Ablation of the gut microbiota alleviates high-methionine diet-induced hyperhomocysteinemia and glucose intolerance in mice

W. Li, Y. Jia, et al.

The use of dietary supplements and vitamin consumption during and after the Covid pandemic in Vietnam: a perspective of user-generated content
Health and Fitness

The use of dietary supplements and vitamin consumption during and after the Covid pandemic in Vietnam: a perspective of user-generated content

M. Ha, G. Nguyen, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny