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Abstract
This paper reports a synergistic strategy to simultaneously improve the photostability, brightness, and Stokes shift of regular fluorophores. Introducing a quinoxaline motif with fine-tuned electron density to conventional rhodamines generates new dyes with a vibronic structure and inhibited twisted-intramolecular-charge-transfer (TICT) formation, increasing brightness and photostability while enlarging the Stokes shift. The new fluorophore YL578 shows superior performance in STED microscopy, exhibiting greater brightness and photostability than existing photostable fluorophores. This strategy is generalizable, offering a new class of bright and photostable fluorescent probes with long Stokes shifts for bioimaging and biosensing.
Publisher
Nature Communications
Published On
Oct 26, 2022
Authors
Gangwei Jiang, Tian-Bing Ren, Elisa D’Este, Mengyi Xiong, Bin Xiong, Kai Johnsson, Xiao-Bing Zhang, Lu Wang, Lin Yuan
Tags
fluorophores
photostability
brightness
Stokes shift
bioimaging
biosensing

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