Biology

A persistent prefrontal reference frame across time and task rules

H. Muysers, H. Chen, et al.

Discover how a unique ensemble of neurons in the medial prefrontal cortex of mice maintains stability in spatial memory tasks, showcasing minimal drift despite changes. This groundbreaking research conducted by Hannah Muysers and colleagues reveals a core neural reference for consistent behaviors over time.

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Abstract

This study investigated the stability of neuronal responses in the medial prefrontal cortex (mPFC) of mice performing an olfaction-guided spatial memory task over several weeks. Researchers found a persistent ensemble of mPFC neurons maintaining trajectory-specific tuning, showing minimal representational drift across long pauses and rule changes. This suggests a 'core ensemble' forming a stable reference frame for consistent behavior over extended periods.

Publisher

Nature Communications

Published On

Mar 08, 2024

Authors

Hannah Muysers, Hung-Ling Chen, Johannes Hahn, Shani Folschweiller, Torfi Sigurdsson, Jonas-Frederic Sauer, Marlene Bartos

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