logo
ResearchBunny Logo
Abstract
This study investigates the synergistic antibacterial activity of a combination of two bacteriocins, garvicin KS and micrococcin P1, against *Staphylococcus aureus* biofilms, including MRSA strains. The bacteriocin combination demonstrated the ability to restore the sensitivity of MRSA strain ATCC 33591 to penicillin G. Metabolic assays, confocal and scanning electron microscopy revealed that the combination potently inhibits cell viability by causing severe cell damage within the biofilms. The findings suggest bacteriocins as valuable therapeutic tools against biofilm-associated MRSA infections.
Publisher
npj Biofilms and Microbiomes
Published On
Dec 02, 2020
Authors
Christian Kranjec, Kirill V. Ovchinnikov, Torstein Grønseth, Kumar Ebineshan, Aparna Srikantam, Dzung B. Diep
Tags
bacteriocins
MRSA
biofilms
garvicin KS
micrococcin P1
penicillin G
antibacterial activity

Related Publications

Explore these studies to deepen your understanding of the subject.

A quasi-experimental controlled study of a school-based mental health programme to improve the self-esteem of primary school children
Education

A quasi-experimental controlled study of a school-based mental health programme to improve the self-esteem of primary school children

M. Iwahori, C. Oshiyama, et al.

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial
Medicine and Health

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial

S. Mukherjee, C. N. Hurt, et al.

Developing a BOPPPS (Bridge-in, Objectives, Pre-assessment, Participatory Learning, Post-assessment and Summary) model combined with the OBE (Outcome Based Education) concept to improve the teaching outcomes of higher education
Education

Developing a BOPPPS (Bridge-in, Objectives, Pre-assessment, Participatory Learning, Post-assessment and Summary) model combined with the OBE (Outcome Based Education) concept to improve the teaching outcomes of higher education

Z. Xu, L. Ge, et al.

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma
Medicine and Health

A type I interferon footprint in pre-operative biopsies is an independent biomarker that in combination with CD8+ T cell quantification can improve the prediction of response to neoadjuvant treatment of rectal adenocarcinoma

A. Rezapour, D. Rydbeck, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny