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A bacteriocin-based antimicrobial formulation to effectively disrupt the cell viability of methicillin-resistant *Staphylococcus aureus* (MRSA) biofilms

Medicine and Health

A bacteriocin-based antimicrobial formulation to effectively disrupt the cell viability of methicillin-resistant *Staphylococcus aureus* (MRSA) biofilms

C. Kranjec, K. V. Ovchinnikov, et al.

This study conducted by Christian Kranjec, Kirill V. Ovchinnikov, Torstein Grønseth, Kumar Ebineshan, Aparna Srikantam, and Dzung B. Diep reveals the promising synergistic antibacterial effects of garvicin KS and micrococcin P1 against *Staphylococcus aureus* biofilms, including MRSA strains. The combination not only inhibits cell viability but also revives MRSA susceptibility to penicillin G, pointing to bacteriocins as potential therapeutic agents against stubborn biofilm infections.

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Playback language: English
Abstract
This study investigates the synergistic antibacterial activity of a combination of two bacteriocins, garvicin KS and micrococcin P1, against *Staphylococcus aureus* biofilms, including MRSA strains. The bacteriocin combination demonstrated the ability to restore the sensitivity of MRSA strain ATCC 33591 to penicillin G. Metabolic assays, confocal and scanning electron microscopy revealed that the combination potently inhibits cell viability by causing severe cell damage within the biofilms. The findings suggest bacteriocins as valuable therapeutic tools against biofilm-associated MRSA infections.
Publisher
npj Biofilms and Microbiomes
Published On
Dec 02, 2020
Authors
Christian Kranjec, Kirill V. Ovchinnikov, Torstein Grønseth, Kumar Ebineshan, Aparna Srikantam, Dzung B. Diep
Tags
bacteriocins
MRSA
biofilms
garvicin KS
micrococcin P1
penicillin G
antibacterial activity

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