Medicine and Health

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

H. Shin, S. Jeong, et al.

Discover the groundbreaking research by Hyogeun Shin, Sohyeon Jeong, Ju-Hyun Lee, Woong Sun, Nakwon Choi, and Il-Joo Cho as they unveil a revolutionary 3D high-density multifunctional microelectrode array. This innovative device enhances our capability to monitor and modulate neural activities, paving the way for advanced in vitro studies in neural circuit dynamics.

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Abstract

Investigation of neural circuit dynamics is crucial for understanding brain function and dysfunction. Current in vitro 3D neural circuit models lack integrated technologies for precise monitoring and modulation of neural activity. This paper presents a 3D high-density multifunctional microelectrode array (MEA) with optical stimulation and drug delivery capabilities. The MEA allows precise measurement of synaptic latencies in 3D neural networks and opens opportunities for in vitro studies of neural circuits using 3D brain models.

Publisher

Nature Communications

Published On

Jan 21, 2021

Authors

Hyogeun Shin, Sohyeon Jeong, Ju-Hyun Lee, Woong Sun, Nakwon Choi, Il-Joo Cho

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