A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages

Effective individual wound management, particularly in cases of prolonged healing and increased infection vulnerability, has prompted the development of wound theranostics, combining real-time diagnostic assessment and on-demand treatment. Here, we present a multifunctional conducting polymer-based smart theranostic bandage that integrates pH sensing, pH-compensated uric acid (UA) biosensing, and on-demand antibiotic release using different conducting polymers, each leveraging their advantageous intrinsic properties. Specifically, the polyaniline-based pH sensor operates reversibly across a pH range of 4–10, while the functionalized poly(3,4-ethylenedioxythiophene)-based UA biosensor exhibits a linear response up to 0.9 mM UA. Simultaneous detection of pH and UA allows accurate UA determination via pH compensation. Upon electrical stimulation, the poly(3,4-ethylenedioxythiophene) based bandage releases ciprofloxacin via a 0.6 V patch, connected to a flexible printed circuit board, and embedded in a wound bandage, offering potential for remote wound monitoring, targeted treatment, and wireless wound management.