This study investigates family responsibility discrimination against men and women in urban China, focusing on work-family interference. Four experiments (N = 2577) reveal that shouldering family responsibilities in contexts of family interference in work (FIW) and work interference in family (WIF) leads to more discrimination against men. Work-family balance (WFB) policies mitigate supervisor discrimination against men in FIW but not observer discrimination in WIF. Post-hoc experiments (N = 931) confirm these findings, highlighting variations across socioeconomic status and industry.