Medicine and Health

Understanding repertoire sequencing data through a multiscale computational model of the germinal center

R. García-valiente, E. M. Tejero, et al.

This study delves into B-cell and T-cell immune receptor repertoires, revealing surprising insights about clonal abundance and affinity variability. Fascinating simulations guide experimental design, enriching our understanding of the adaptive immune response. The research was conducted by Rodrigo García-Valiente, Elena Merino Tejero, Maria Stratigopoulou, Daria Balashova, Aldo Jongejan, Danial Lashgari, Aurélien Pélissier, Tom G. Caniels, Mathieu A. F. Claireaux, Anne Musters, Marit J. van Gils, María Rodríguez Martínez, Niek de Vries, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, and Antoine H. C. van Kampen.