Medicine and Health

Two-year safety outcomes of iPS cell-derived mesenchymal stromal cells in acute steroid-resistant graft-versus-host disease

K. Kelly, A. J. C. Bloor, et al.

This clinical trial found that 60% of participants with steroid-resistant acute graft-versus-host disease survived after two years of treatment with iPS cell-derived mesenchymal stromal cells (CYP-001). Impressively, there were no serious adverse events or safety concerns reported, indicating that this innovative therapy is both safe and well-tolerated. This research was conducted by Kilian Kelly, Adrian J. C. Bloor, James E. Griffin, Rohini Radia, David T. Yeung, and John E. J. Rasko.

00:00

Playback language: English

Index

Abstract

This study reports the two-year safety and efficacy outcomes of a clinical trial involving 15 participants with steroid-resistant acute graft-versus-host disease (GvHD) treated with iPS cell-derived mesenchymal stromal cells (CYP-001). At the two-year mark, 60% of participants survived. Deaths were attributed to common complications in allogeneic hematopoietic stem cell transplantation recipients and were not considered treatment-related. No serious adverse events, tumors, or other safety concerns associated with CYP-001 were observed. The results suggest that systemic delivery of iPS cell-derived cells is safe and well-tolerated over a two-year period.

Publisher

Nature Medicine

Published On

May 22, 2024

Authors

Kilian Kelly, Adrian J. C. Bloor, James E. Griffin, Rohini Radia, David T. Yeung, John E. J. Rasko

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Neuroprotective Effects of Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Extracellular Vesicles in Ischemic Stroke Models

G. Lu, X. Su, et al.

Veterinary Science

Evaluation of enzymatic protocols to optimize efficiency of bovine adipose tissue-derived mesenchymal stromal cell isolation

E. Heyman, B. Devriendt, et al.

Psychology

Safety and Tolerability of the Acute Ketamine Treatment in Treatment-Resistant Depression: Focus on Comorbidities Interplay with Dissociation and Psychomimetic Symptoms

A. Włodarczyk, A. Dywel, et al.

Economics

The role of public versus private social safety nets in mitigating the impact of shocks in rural Pakistan

S. Naveed, A. I. Malik, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny