Psychology

Safety and Tolerability of the Acute Ketamine Treatment in Treatment-Resistant Depression: Focus on Comorbidities Interplay with Dissociation and Psychomimetic Symptoms

A. Włodarczyk, A. Dywel, et al.

This groundbreaking study by Adam Włodarczyk, Alicja Dywel, and Wiesław Jerzy Cubała explores the safety of intravenous ketamine for treatment-resistant depression in patients with major depressive disorder and bipolar depression. It uncovers significant findings related to epilepsy and the effects of comorbidities, emphasizing the need for vigilant clinical supervision during treatment.

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Abstract

This study investigated the safety of intravenous ketamine treatment for treatment-resistant depression (TRD) in patients with major depressive disorder (MDD) and bipolar depression (BP), focusing on the interplay between comorbidities, dissociation, and psychomimetic symptoms. 49 inpatients received ketamine infusions. Epilepsy was significantly associated with increased Brief Psychiatric Rating Scale (BPRS) scores over time. Other comorbidities showed insignificant effects on psychotic symptomatology. Post-dose CADSS and BPRS scores decreased after each infusion, except in the epilepsy subgroup. The study highlights the importance of considering comorbidities and concomitant medication when administering ketamine, emphasizing the need for close clinical supervision.

Publisher

Pharmaceuticals

Published On

Jan 24, 2023

Authors

Adam Włodarczyk, Alicja Dywel, Wiesław Jerzy Cubała

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