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Abstract
Pancreatic cancer (PC) has a grim prognosis, and new therapies are urgently needed. This study investigated the antitumor activity of Oba01, an antibody-drug conjugate (ADC) targeting death receptor 5 (DR5), in preclinical PC models. Oba01 demonstrated potent in vitro and in vivo antitumor activity in DR5-positive PC cells and xenografts, mediated through apoptosis induction, G2/M phase growth arrest, bystander effect, antibody-dependent cell-mediated cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC). A synergistic effect was observed when Oba01 was combined with gemcitabine, enhancing antiproliferative activity both in vitro and in vivo. These results suggest Oba01 holds promise as a novel therapeutic approach for DR5-expressing PC.
Publisher
Cell Death and Disease
Published On
Jan 01, 2023
Authors
Chao Zheng, Dongdong Zhou, Weisong Li, Yanhui Duan, Minwen Xu, Jie Liu, Jingpei Cheng, Youban Xiao, Han Xiao, Tao Gan, Jianmin Liang, Dexian Zheng, Liefeng Wang, Shuyong Zhang
Tags
pancreatic cancer
antibody-drug conjugate
Oba01
DR5
synergistic effect
apoptosis
gemcitabine

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