Biology

The specialist in regeneration—the Axolotl—a suitable model to study bone healing?

A. Polikarpova, A. Ellinghaus, et al.

This study reveals a new surgical technique to enhance limb healing in axolotls, demonstrating that stabilized femur osteotomies heal more efficiently than non-stabilized procedures. Conducted by A. Polikarpova and colleagues, it suggests endochondral ossification as a mechanism similar to mammals, paving the way for controlled bone healing experiments.

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Playback language: English

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Abstract

While axolotls can fully regenerate amputated limbs, their bone fracture healing mechanism is unclear. This study presents a surgical technique to stabilize axolotl femur osteotomies using a fixator plate, comparing it to non-stabilized osteotomy and limb amputation. Plate-fixated femurs healed more efficiently. Similar to mice, PCNA+ proliferating cells and SOX9-expressing cells were observed in early stages, suggesting endochondral ossification as the healing mechanism. This standardized fixation technique enables controlled axolotl bone healing experiments comparable to mammals.

Publisher

npj Regenerative Medicine

Published On

Jun 30, 2022

Authors

A. Polikarpova, A. Ellinghaus, O. Schmidt-Bleek, L. Grosser, C. H. Bucher, G. N. Duda, E. M. Tanaka, K. Schmidt-Bleek

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