Medicine and Health

The single-cell transcriptomic atlas iPain identifies senescence of nociceptors as a therapeutical target for chronic pain treatment

P. Techameena, X. Feng, et al.

Chronic pain affects nearly 20% of adults worldwide and remains inadequately treated. This groundbreaking research by Prach Techameena, Xiaona Feng, Kaiwen Zhang, and Saida Hadjab unveils the role of nociceptor senescence in chronic pain progression. With promising senolytic treatments shown to alleviate pain in mice, the study highlights a potential breakthrough in pain management.

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Abstract

Chronic pain, affecting roughly 20% of adults globally, lacks effective treatments. This study leverages the iPain single-cell atlas to investigate chronic pain progression in dorsal root and trigeminal ganglia. Researchers discovered that senescence of a subset of nociceptors drives chronic pain, a mechanism observed in animal models and human patients. Senolytic treatment reversed pain symptoms in mice, highlighting the therapeutic potential of targeting cellular senescence in chronic pain.

Publisher

Nature Communications

Published On

Oct 04, 2024

Authors

Prach Techameena, Xiaona Feng, Kaiwen Zhang, Saida Hadjab

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