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Abstract
This study utilized untargeted LC-MS metabolomics on 1425 saliva samples from children and their caregivers to investigate the salivary metabolome and its associations with inflammation, antioxidant potential, environmental tobacco smoke (ETS) exposure, metabolic regulation, and heavy metals. Children and caregivers showed similar salivary metabolomes, with most metabolomic variation explained by dyad. Two distinct metabotypes were identified across the population. Several metabolites correlated with the biomeasures and heavy metals, suggesting implications for family environment effects on metabolomic variation and human health.
Publisher
npj Metabolic Health and Disease
Published On
Aug 13, 2024
Authors
Jason A. Rothman, Hillary L. Piccerillo, Sage J. B. Dunham, Jenna L. Riis, Douglas A. Granger, Elizabeth A. Thomas, Katrine L. Whiteson
Tags
salivary metabolome
metabolomics
inflammation
heavy metals
environmental tobacco smoke
children
caregivers

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