This study investigates the influence of various mountain ranges on the global thermohaline circulation using coupled model sensitivity experiments. The results highlight the Tibetan Plateau's crucial role in establishing the Atlantic MOC (AMOC) and inhibiting the Pacific MOC (PMOC). The Antarctic continent also significantly aids in AMOC formation. The Tibetan Plateau's modification of the global hydrological cycle is identified as a key factor in shaping the global thermohaline circulation.