Medicine and Health

The influence of body composition on the response to dynamic stimulation of the endocrine pituitary-testis axis

J. Abildgaard, A. K. Bang, et al.

This research, conducted by Julie Abildgaard, Anne Kirstine Bang, Loa Nordkap, Lærke Priskorn, and Niels Jørgensen, examines how body composition affects the hormonal responses in men. Interestingly, while higher BMI correlates with lower levels of key hormones like testosterone, the dynamic responses to hormonal stimulation might provide crucial insights for managing obesity-related testosterone deficiencies.

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Abstract

This study investigated the association between body composition and dynamic responses of the pituitary-testis axis in men. A higher BMI was associated with lower basal serum LH and testosterone, and free testosterone. However, the GnRH-stimulated LH increase and HCG-stimulated testosterone increase were less dependent on BMI. Dynamic sex hormone responses following pituitary-testis axis stimulation could potentially assist clinical decision-making in patients with obesity suspected of testosterone deficiency.

Publisher

International Journal of Obesity

Published On

Apr 12, 2024

Authors

Julie Abildgaard, Anne Kirstine Bang, Loa Nordkap, Lærke Priskorn, Niels Jørgensen

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