Medicine and Health

The influence of acute lifestyle changes on NAFLD evolution in a multicentre cohort: a matter of body composition

M. Dallio, M. Sangineto, et al.

This research reveals the alarming effects of COVID-19 lockdown on Non-alcoholic fatty liver disease (NAFLD) in 187 Italian patients over four years. The study highlights significant increases in fat and carbohydrate intake, decreased physical activity, and a troubling rise in hepatocellular carcinoma (HCC) incidence linked to body composition changes. Conducted by Marcello Dallio and colleagues, this study underscores the importance of addressing lifestyle factors in managing liver health during unprecedented times.

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Abstract

This study investigated the impact of acute lifestyle changes during the COVID-19 lockdown on Non-alcoholic fatty liver disease (NAFLD) progression in 187 Italian patients over four years. Lockdown led to increased fat and carbohydrate intake, reduced physical activity, and worsened metabolic parameters. Body composition showed increased fat mass and decreased lean mass. Hepatocellular carcinoma (HCC) incidence significantly increased during lockdown, with a stronger association between HCC and body composition changes than other metabolic factors.

Publisher

Nutrition and Diabetes

Published On

May 27, 2024

Authors

Marcello Dallio, Moris Sangineto, Mario Romeo, Marina Cipullo, Annachiara Coppola, Simone Mammone, Giuseppe Di Gioia, Mario Masarone, Marcello Persico, Gaetano Serviddio, Alessandro Federico

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