logo
ResearchBunny Logo
Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Medicine and Health

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

S. Zumerle, M. Sarill, et al.

Discover how *Salvia haenkei* extract (Haenkenium, HK) has been shown to extend lifespan and healthspan in aged mice, while combating age-related inflammation and senescence. This groundbreaking research, led by a team at the Veneto Institute of Molecular Medicine, unveils the promising effects of luteolin in improving muscle strength and fur thickness. Dive into the findings that may change the landscape of aging research!

00:00
Playback language: English
Abstract
Accumulating senescent cells contribute to aging and age-related diseases. This study shows that a *Salvia haenkei* extract (Haenkenium, HK) extended lifespan and healthspan in aged mice. HK inhibited age-induced inflammation, fibrosis, and senescence markers, improving muscle strength and fur thickness. It also reduced doxorubicin-induced senescence. Luteolin, a flavonoid in HK, disrupted the p16–CDK6 interaction, suggesting a mechanism for senescence inhibition.
Publisher
Nature Aging
Published On
Jul 01, 2024
Authors
Sara Zumerle, Miles Sarill, Miriam Saponaro, Manuel Colucci, Liliana Contu, Edoardo Lazzarini, Roberta Sartori, Camilla Pezzini, Anna Rinaldi, Anna Scanu, Jacopo Sgrignani, Patrizia Locatelli, Marianna Sabbadin, Aurora Valdata, Daniela Brina, Isabella Giacomini, Beatrice Rizzo, Alessandra Pierantoni, Saman Sharifi, Silvia Bressan, Claudia Altomare, Yulia Goshovska, Chiara Giraudo, Roberto Luisetto, Luca Iaccarino, Cristina Torcasio, Simone Mosole, Emiliano Pasquini, Andrea Rinaldi, Laura Pellegrini, Gregorio Peron, Matteo Fassan, Stefano Masiero, Andrea Maria Giori, Stefano Dall’Acqua, Johan Auwerx, Pietro Cippà, Andrea Cavalli, Marco Bolis, Marco Sandri, Lucio Barile, Monica Montopoli, Andrea Alimonti
Tags
senescent cells
aging
Salvia haenkei
inflammation
healthspan
luteolin
muscle strength

Related Publications

Explore these studies to deepen your understanding of the subject.

Psychological and ethical issues raised by genomic in paediatric care pathway, a qualitative analysis with parents and childhood cancer patients
Medicine and Health

Psychological and ethical issues raised by genomic in paediatric care pathway, a qualitative analysis with parents and childhood cancer patients

M. Droin-mollard, S. D. Montgolfier, et al.

Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort
Medicine and Health

Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort

A. S. Thompson, A. Jennings, et al.

Ovarian follicular dynamics, progesterone concentrations, pregnancy rates and transcriptional patterns in *Bos indicus* females with a high or low antral follicle count
Veterinary Science

Ovarian follicular dynamics, progesterone concentrations, pregnancy rates and transcriptional patterns in *Bos indicus* females with a high or low antral follicle count

M. A. D. Lima, F. Morotti, et al.

AV futures or futures with AVs? Bridging sociotechnical imaginaries and a multi-level perspective of autonomous vehicle visualisations in praxis
Transportation

AV futures or futures with AVs? Bridging sociotechnical imaginaries and a multi-level perspective of autonomous vehicle visualisations in praxis

R. Martin

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny