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Targeted delivery of the probiotic *Saccharomyces boulardii* to the extracellular matrix enhances gut residence time and recovery in murine colitis

Medicine and Health

Targeted delivery of the probiotic *Saccharomyces boulardii* to the extracellular matrix enhances gut residence time and recovery in murine colitis

M. K. Heavey, A. Hazelton, et al.

Discover how engineered *Saccharomyces boulardii* can revolutionize treatment for inflammatory bowel diseases by improving gut residence time and colon concentration. This groundbreaking research was conducted by a team of experts including Mairead K. Heavey and Anthony Hazelton.

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Playback language: English
Abstract
Engineered probiotic microbes are emerging as pharmaceutical agents for treating inflammatory conditions. This study engineered *Saccharomyces boulardii* to bind to extracellular matrix (ECM) proteins in the gut using antibody surface display. This resulted in a 24–48 h increase in gut residence time and 100-fold higher colon concentrations in colitis models. Improved pharmacodynamic parameters (colon length, cytokine expression, inflammation scores) were observed, highlighting the potential for targeted microbial therapeutics in inflammatory bowel diseases.
Publisher
Nature Communications
Published On
May 06, 2024
Authors
Mairead K. Heavey, Anthony Hazelton, Yuyan Wang, Mitzy Garner, Aaron C. Anselmo, Janelle C. Arthur, Juliane Nguyen
Tags
probiotic
inflammatory bowel diseases
gut microbiome
pharmaceutical agents
targeted therapy
colon concentration
inflammation

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