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Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model

Health and Fitness

Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model

T. Zhang, W. Zhang, et al.

Explore groundbreaking research by Tao Zhang and colleagues showing that postbiotics derived from *Bifidobacterium adolescentis* may offer a safer and more effective alternative to probiotics for managing ulcerative colitis, significantly enhancing fecal microbiota diversity and composition.

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Playback language: English
Abstract
This study compared the effects of probiotics and postbiotics derived from *Bifidobacterium adolescentis* B8589 in a mouse colitis model. Both improved colitis symptoms (decreased histology scores), but postbiotics showed stronger effects on modulating fecal microbiota beta diversity, composition, and metagenomic potential. The authors suggest postbiotics are a safer and more effective alternative to probiotics for managing ulcerative colitis.
Publisher
npj Science of Food
Published On
Nov 15, 2022
Authors
Tao Zhang, Weiqin Zhang, Cuijiao Feng, Lai-Yu Kwok, Qiuwen He, Zhihong Sun
Tags
probiotics
postbiotics
ulcerative colitis
microbiota
Bifidobacterium adolescentis
health
mouse model

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