This review summarizes advancements in protein nanoparticle technology for cancer therapy. It discusses tailored construction methods and therapeutic applications of engineered protein-based nanoparticles, focusing on their tumor-targeting capabilities, overcoming multidrug resistance, and mimicking the tumor microenvironment. The review highlights various protein nanoparticles such as ferritins, vaults, encapsulins, small heat shock proteins, and elastin-like polypeptides, detailing their recombinant production, functionalization, drug loading methods, and applications.

R Jayachandra Babu, Amit K Tiwari, Mohamed A A Abdelhamid, Mi-Ran Ki, Amer Ali, Abd El-Hafeez, Ryeo Gang, Son, Seung Pil Pack