Gastric cancer is a significant global health concern, ranking fourth in both incidence and mortality. Despite advancements in chemotherapy, median survival remains limited (12-15 months). This review examines recent progress in immunotherapy and molecular targeted therapies for gastric cancer, focusing on immune checkpoint inhibitors (ICIs) and their combinations with cytotoxic and targeted agents. Clinical trials demonstrate potential benefits, particularly with anti-PD-1/PD-L1 inhibitors, and ongoing research explores combination strategies to improve outcomes.
Publisher
Future Science OA
Published On
Mar 17, 2023
Authors
Yuri Yoshinami, Hirokazu Shoji
Tags
gastric cancer
immunotherapy
immune checkpoint inhibitors
molecular targeted therapies
clinical trials
PD-1
survival
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