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T-cells produce acidic niches in lymph nodes to suppress their own effector functions

Medicine and Health

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

H. Wu, V. Estrella, et al.

This groundbreaking research reveals how the acidic environment of tumors inhibits the function of activated CD8+ T-cells, suggesting a physiological mechanism in immune regulation. Conducted by leading experts in cancer immunology, the study uncovers the role of acidic niches in lymph nodes and their impact on T-cell metabolism and activation.

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