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Systematic detection of co-infection and intra-host recombination in more than 2 million global SARS-CoV-2 samples

Medicine and Health

Systematic detection of co-infection and intra-host recombination in more than 2 million global SARS-CoV-2 samples

O. A. Pipek, A. Medgyes-horváth, et al.

In an extensive analysis of over 2 million SARS-CoV-2 samples, this research delves into the intriguing realm of co-infections and intra-host recombination. With a co-infection rate of just 0.35%, and the identification of three recombination hotspots in Delta and Omicron BA.1 variants, this study reveals critical insights into viral behavior. Authored by Orsolya Anna Pipek and colleagues, this research sheds light on complex challenges in viral detection methods.

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Playback language: English
Abstract
This study systematically analyzed over 2 million SARS-CoV-2 samples from the European COVID-19 Data Portal to detect co-infections and intra-host recombination. Co-infection was found in 0.35% of samples. Two methods were used to detect recombination, highlighting challenges like PCR artifacts. Three recombination hotspots were identified in Delta and Omicron BA.1 recombinants.
Publisher
Nature Communications
Published On
Jan 15, 2024
Authors
Orsolya Anna Pipek, Anna Medgyes-Horváth, József Stöger, Krisztián Papp, Dávid Visontai, Marion Koopmans, David Nieuwenhuijse, Bas B. Oude Munnik, VEO Technical Working Group, István Csabai
Tags
SARS-CoV-2
co-infections
intra-host recombination
PCR artifacts
recombination hotspots
Delta variant
Omicron BA.1

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