This study fabricated bioactive scaffolds by incorporating strontium (Sr) into amino-functional mesoporous bioactive glass (MBG) to enhance bone regeneration in osteoporosis. In vitro and in vivo studies in an osteoporotic rat model demonstrated improved biocompatibility, osteogenesis, and angiogenesis with Sr incorporation. Bioinformatics analysis revealed that Sr-incorporated scaffolds reduced reactive oxygen species by activating the cAMP/PKA pathway, thus promoting osteogenesis and exhibiting an anti-osteoporosis effect. The findings highlight the potential of incorporating trace elements into scaffolds for bone regeneration in osteoporosis.

Qianju Wu, Longwei Hu, Ran Yan, Junfeng Shi, Hao Gu, Yuwei Deng, Ruixue Jiang, Jin Wen, Xinquan Jiang