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Abstract
Stigmasterol (ST) improves lipid and bile acid (BA) metabolism. This study investigated ST's mechanism in preventing dyslipidemia via BA metabolism. ST treatment alleviated high-fat diet (HFD)-induced lipid metabolism disorder. Fecal microbiota transplantation from ST-treated rats showed similar protective effects. ST reversed HFD-induced gut microbiota dysbiosis, modifying serum and fecal BA metabolome profiles, particularly CYP7A1-mediated pathways. Chenodeoxycholic acid (CDCA) combined with ST amplified therapeutic effects. ST benefits against HFD-induced hyperlipidemia and obesity are partially due to intestinal microbiota reprogramming and BA metabolism in enterohepatic circulation. This suggests the gut microbiota as a potential target for HFD-induced dyslipidemia treatment.
Publisher
npj Science of Food
Published On
Aug 27, 2022
Authors
Yaxin Zhang, Yuyan Gu, Jing Jiang, Xiaobing Cui, Saibo Cheng, Linling Liu, Zhiyong Huang, Rongxin Liao, Peng Zhao, Jieying Yu, Jing Wang, Yuhua Jia, Wen Jin, Fenghua Zhou
Tags
Stigmasterol
dyslipidemia
bile acid metabolism
gut microbiota
high-fat diet
lipid metabolism
therapeutic effects

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