Medicine and Health

Stigmasterol attenuates hepatic steatosis in rats by strengthening the intestinal barrier and improving bile acid metabolism

Y. Zhang, Y. Gu, et al.

Discover how stigmasterol (ST) acts as a powerful ally against high-fat diet-induced dyslipidemia! This groundbreaking research by Yaxin Zhang and colleagues reveals ST's remarkable ability to improve lipid and bile acid metabolism while promoting gut microbiota health. Dive into the nuances of enterohepatic circulation and explore the potential of gut microbiota as a target for treatment.

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Playback language: English

Index

Abstract

Stigmasterol (ST) improves lipid and bile acid (BA) metabolism. This study investigated ST's mechanism in preventing dyslipidemia via BA metabolism. ST treatment alleviated high-fat diet (HFD)-induced lipid metabolism disorder. Fecal microbiota transplantation from ST-treated rats showed similar protective effects. ST reversed HFD-induced gut microbiota dysbiosis, modifying serum and fecal BA metabolome profiles, particularly CYP7A1-mediated pathways. Chenodeoxycholic acid (CDCA) combined with ST amplified therapeutic effects. ST benefits against HFD-induced hyperlipidemia and obesity are partially due to intestinal microbiota reprogramming and BA metabolism in enterohepatic circulation. This suggests the gut microbiota as a potential target for HFD-induced dyslipidemia treatment.

Publisher

npj Science of Food

Published On

Aug 27, 2022

Authors

Yaxin Zhang, Yuyan Gu, Jing Jiang, Xiaobing Cui, Saibo Cheng, Linling Liu, Zhiyong Huang, Rongxin Liao, Peng Zhao, Jieying Yu, Jing Wang, Yuhua Jia, Wen Jin, Fenghua Zhou

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