This study utilizes single-cell transcriptomics to investigate the cellular mechanisms underlying cancer-associated adipose wasting (CAC). Researchers analyzed white adipose tissue from patients with and without CAC, identifying depot- and disease-specific changes in adipose progenitors and immune cells. Pro-inflammatory transitions were observed in adipose progenitors, macrophages, and CD8⁺ T cells in CAC patients, along with remodeled cell interactions. Activated CD8⁺ T cells showed increased IFNG expression and a pro-catabolic effect on adipocytes. Macrophage depletion alleviated cachexia in a CAC animal model. The findings suggest a causative role for chronic inflammation and immune cell dysregulation in adipose wasting during CAC.
Publisher
Cell Discovery
Published On
Authors
Jun Han, Yuchen Wang, Yan Qiu, Diya Sun, Yan Liu, Zhigang Li, Ben Zhou, Haibing Zhang, Yichuan Xiao, Guohao Wu, Qiu Rong Ding
Tags
cancer-associated adipose wasting
chronic inflammation
immune cell dysregulation
adipose progenitors
cell interactions
cachexia
transcriptomics
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