Medicine and Health

Single-cell sequencing unveils key contributions of immune cell populations in cancer-associated adipose wasting

J. Han, Y. Wang, et al.

This study explores the intriguing role of chronic inflammation and immune cell dysregulation in cancer-associated adipose wasting (CAC), shedding light on the specific changes in adipose progenitors and immune cells. Conducted by Jun Han, Yuchen Wang, Yan Qiu, Diya Sun, Yan Liu, Zhigang Li, Ben Zhou, Haibing Zhang, Yichuan Xiao, Guohao Wu, and Qiu Rong Ding, this research reveals how activated immune responses impact adipose tissue during CAC.

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Abstract

This study utilizes single-cell transcriptomics to investigate the cellular mechanisms underlying cancer-associated adipose wasting (CAC). Researchers analyzed white adipose tissue from patients with and without CAC, identifying depot- and disease-specific changes in adipose progenitors and immune cells. Pro-inflammatory transitions were observed in adipose progenitors, macrophages, and CD8⁺ T cells in CAC patients, along with remodeled cell interactions. Activated CD8⁺ T cells showed increased IFNG expression and a pro-catabolic effect on adipocytes. Macrophage depletion alleviated cachexia in a CAC animal model. The findings suggest a causative role for chronic inflammation and immune cell dysregulation in adipose wasting during CAC.

Publisher

Cell Discovery

Published On

Authors

Jun Han, Yuchen Wang, Yan Qiu, Diya Sun, Yan Liu, Zhigang Li, Ben Zhou, Haibing Zhang, Yichuan Xiao, Guohao Wu, Qiu Rong Ding

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