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High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis

Medicine and Health

High resolution mapping of the tumor microenvironment using integrated single-cell, spatial and in situ analysis

A. Janesick, R. Shelansky, et al.

This groundbreaking study conducted by Amanda Janesick and colleagues from 10x Genomics Inc. reveals the potential of integrating cutting-edge single-cell and spatial technologies to provide new insights into breast cancer. By analyzing FFPE human breast cancer sections, they identify key molecular differences between tumor regions and highlight rare boundary cells that may play a role in cancer progression. Discover how this research could transform oncology diagnostics and therapeutics.

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Playback language: English
Abstract
Single-cell and spatial technologies are revolutionizing the study of molecular states in clinical samples. This study combines single-cell (scFFPE-seq), spatial (Visium CytAssist), and in situ (Xenium) technologies to analyze FFPE human breast cancer sections. Integration of these technologies reveals molecular differences between tumor regions, identifies biomarkers involved in cancer progression, and identifies rare boundary cells at the myoepithelial border. The authors demonstrate that integrating these technologies provides deeper insights than using each technology alone, advancing oncology research and the development of diagnostics and therapeutics.
Publisher
Nature Communications
Published On
Dec 19, 2023
Authors
Amanda Janesick, Robert Shelansky, Andrew D. Gottscho, Florian Wagner, Stephen R. Williams, Morgane Rouault, Ghezal Beliakoff, Carolyn A. Morrison, Michelli F. Oliveira, Jordan T. Sicherman, Andrew Kohlway, Jawad Abousoud, Tingsheng Yu Drennon, Seayar H. Mohabbat, 10x Development Teams, Sarah E. B. Taylor
Tags
single-cell technology
spatial analysis
breast cancer
molecular differences
biomarkers
tumor regions
FFPE
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