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Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task

Medicine and Health

Similar cognitive deficits in mice and humans in the chronic phase post-stroke identified using the touchscreen-based paired-associate learning task

W. Z. Chow, L. K. Ong, et al.

This study by Wei Zhen Chow and team investigates post-stroke cognitive function using a novel touchscreen-based learning task. Findings reveal that chronic stroke survivors have reduced cognitive performance compared to age-matched controls, with striking parallels observed in post-stroke mice. Discover how this research could inform future therapies aimed at enhancing cognitive recovery after stroke.

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Playback language: English
Abstract
This study assessed post-stroke cognitive function using a comparable touchscreen-based paired-associate learning (PAL) task in chronic stroke survivors (≥ 5 months post-stroke, n=70), age-matched controls (n=70), and in mice (six months post-stroke). Stroke survivors showed significantly fewer correct choices than controls, mirroring similar impairment in post-stroke mice. This highlights the potential of analogous modelling using parallel cross-species test platforms for evaluating therapies to improve long-term cognitive function post-stroke.
Publisher
Scientific Reports
Published On
Nov 11, 2020
Authors
Wei Zhen Chow, Lin Kooi Ong, Murielle G. Kluge, Prajwal Gyawali, Frederick R. Walker, Michael Nilsson
Tags
post-stroke
cognitive function
touchscreen-based learning
chronic stroke survivors
cross-species modeling
therapy evaluation
paired-associate learning

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