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Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance

Medicine and Health

Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance

A. Nicot, P. Yecham, et al.

Using trace conditioning in mice, research conducted by Amélia Nicot, Pavankumar Yecham, Ilana Serin, David J. Barker, and Lauren K. Dobbs shows that acute cocaine can produce a transient negative affective state linked to conditioned place avoidance; this aversion correlates with low ventral striatal dynorphin (Pdyn) and a low Pdyn:Penk ratio, while higher striatal Pdyn confers resistance to cocaine-induced avoidance, suggesting dynorphin has opposing roles in intoxication versus withdrawal.... show more
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