Medicine and Health

Sexual behavior is linked to changes in gut microbiome and systemic inflammation that lead to HIV-1 infection in men who have sex with men

H. Lin, Y. Chen, et al.

This groundbreaking research explores how sexual behavior influences gut microbiome health, systemic inflammation, and the risk of HIV-1 infection among men who have sex with men. Conducted by a team of experts including Huang Lin, Yue Chen, and others, it reveals that unprotected receptive intercourse is linked to heightened inflammatory responses and altered gut microbiota before HIV-1 infection occurs.

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Abstract

This study investigates the link between sexual behavior, gut microbiome changes, systemic inflammation, and HIV-1 infection in men who have sex with men (MSM). It finds that unprotected receptive intercourse is associated with increased proinflammatory cytokines and decreased abundance of specific gut bacteria before HIV-1 infection, suggesting these factors mediate the effect of sexual behavior on HIV-1 acquisition.

Publisher

Communications Biology

Published On

Sep 26, 2024

Authors

Huang Lin, Yue Chen, Grace Abor-Lacks, Meaghan Price, Alison Morris, Jing Sun, Frank Palella, Kara W. Chew, Todd T. Brown, Charles R. Rinaldo, Shyamal D. Peddada

DOI

https://doi.org/10.1038/s42003-024-06816-z

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