Medicine and Health

Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging

X. Feng, L. Wang, et al.

This groundbreaking study by Xu Feng and colleagues uncovers how age-related infiltration of pro-inflammatory S100A8+ immune cells compromises the function of brown adipose tissue (BAT). The researchers discovered that targeting these senescent immune cells could rejuvenate BAT and boost metabolic function in aged individuals. Don't miss out on this timely research that paves the way for future therapies against obesity and metabolic disorders!

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Abstract

Brown adipose tissue (BAT)-mediated thermogenesis declines with age. This study reveals that bone marrow-derived pro-inflammatory and senescent S100A8+ immune cells invade BAT during aging, compromising axonal networks. Senescent immune cells secrete S100A8, inhibiting adipose RNA-binding motif protein 3 (RBM3) expression, leading to impaired sympathetic innervation and thermogenic function. Human S100A8+ immune cells also induce BAT dysfunction. The S100A8 inhibitor paquinimod rejuvenates BAT and improves metabolic function in aged mice. Targeting senescent immune cells may improve BAT aging and related metabolic disorders.

Publisher

Nature Communications

Published On

Jun 02, 2023

Authors

Xu Feng, Liwen Wang, Ruoyu Zhou, Rui Zhou, Linyun Chen, Hui Peng, Yan Huang, Qi Guo, Xianghang Luo, Haiyan Zhou

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