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Abstract
Brown adipose tissue (BAT)-mediated thermogenesis declines with age. This study reveals that bone marrow-derived pro-inflammatory and senescent S100A8+ immune cells invade BAT during aging, compromising axonal networks. Senescent immune cells secrete S100A8, inhibiting adipose RNA-binding motif protein 3 (RBM3) expression, leading to impaired sympathetic innervation and thermogenic function. Human S100A8+ immune cells also induce BAT dysfunction. The S100A8 inhibitor paquinimod rejuvenates BAT and improves metabolic function in aged mice. Targeting senescent immune cells may improve BAT aging and related metabolic disorders.
Publisher
Nature Communications
Published On
Jun 02, 2023
Authors
Xu Feng, Liwen Wang, Ruoyu Zhou, Rui Zhou, Linyun Chen, Hui Peng, Yan Huang, Qi Guo, Xianghang Luo, Haiyan Zhou
Tags
brown adipose tissue
thermogenesis
S100A8
immune cells
aging
metabolic disorders

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